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Chapter 12 Blog: Gene Expression at the Molecular Level (Pankhuri)

Page history last edited by Pankhuri Garg 13 years, 4 months ago

B.  Useful Materials

 

 

1. Frequency of Mismatch Repair Deficiency in Ovarian Cancer - This journal states that the lack of Mis-Match Repair (MMR) proteins may be a vital cause of Ovarian Cancer. People suffering from ovarian cancer, suffer from MMR deficiency. When a RNA is wrongly transcripted, the MMR protein repairs it and replaces it with the correct nucleotide. If it is not repaired, the mRNA goes on to translate a wrong protein. Lack of MMR, improves survival of cancer-affected sights. 

 

2. RNA Splicing

 

 

 

This video gives a fairly detailed crash-course about RNA splicing. It clearly states every step of RNA splicing, as well as mention all components of the process and the RNAs. I really liked how its clear to understand what the process is. 

 

3. Prokaryotic RNA Transcription and Translation

 

 

This image clearly shows that in bacteria, mRNA is translated while being transcripted. Because bacteria lack cell membranes, both process must occur at the same time. One RNA strand can code for several different proteins. In contrast, in eukaryotes, the RNA is transcripted inside the nucleus and spliced to specify coding for only one protein. The mRNA is then transferred to the cytoplasm, and then translated to synthesize proteins.  

 

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