In the first section of this page, you will write a daily summary of that day's class.  For example in  your chapter 2 blog, your first entry should be titled 9/3/10.  You should then write a one or two paragraph summary of that day's lecture, outlining the major points.  In the second section, you are required to add two items (link to a website, video, animation, student-created slide show, student-created PowerPoint presentation) and one journal article pertaining to a topic in this chapter.  A one-paragraph summary must accompany each item describing the main idea and how it applies to the lecture topic.  Please see the PBWorks help guide for assistance embedding video and other items directly in the page.  I will also produce a how-to video on using tables to wrap text around items and other useful tips.  Please see the syllabus for organization and grading details.

A.  Daily Blog

9/22/10- Todays lecture was focused mainly on cell organelles and their functions within the cells. We started off by learning the difference between proakryotes (no nucleus or membrane bound organelles) and eukaryotes. Next we learned the concept of a proteome, which is the proteins expressed by the genome. The proteome is what allows all of the cells that have identical DNA to have different structure and function. Afterwards we reviewed the endomembrane system, whose main function is transporting cargo throughout the cell. To finish off class we were presented with "Pulse-Chase" experiment, in which we were given a group of isomers and asked to determine which would be most useful at tracing proteins. It was determined that S-35 would be most useful because sulfur is the only element that is found solely in amino acids, and not carbohydrates or lipids. 

9/24/10- Todays class started off with a bang, when Dr. Weber announced that the whole class will be receiving iPod touches for using during lab and lecture. This created a palpable energy in the room as the limitless potentials passed through everyones head.  Now onto the lecture. Today we focused again on proteins, and specifically the transport of proteins and what mechanisms and structures are used to ensure that proteins end up where they need to be in the cell. The main regulator of these movements are signal recognition proteins, which are sequences of amino acids that latch onto protein and send it to the ER, where it is subsequently cleaved. In addition we reviewed ER signaling sequences, and how they direct proteins to where they need to be. To be honest, I struggled with this section and I plan on viewing a video lecture so I can fully understand all of the different movements and mechanisms involved in protein trafficking, 

B.  Useful Materials

	This video explains the method through which proteins move through the cell and how they end up where they need to be.
	This diagram sums up the processes of transcription and translation which are responsible for protein synthesis, and it is essential to know this process inside and out in order to fully understand and appreciate protein trafficking.
Intracellular Trafficking and Synaptic Function of APL-1 in Caenorhabditis elegans	This article discusses the function of protein trafficking in the nematode Caenorhabditis elegans, and specifically that of APL-1 within the organism. The study of APL-1 in the nematode is specifically geared towards how the loss of APL-1 negatively affects the organism, and this article says that lethality and molting occurs, however once full-length APL-1 is reinserted, rescuing the cell and indicating that the extracellular region of the cell is essential for viability. In addition, this study has shown that APL-1 plays a pivotal role in synaptic function, which is useful for neurological applications such as the study of Alzheimer's.