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Chapter 11: Nucelic Acid Structure, DNA Replicaiton, and Chromosome Structure (Kimberley)

Page history last edited by KimberleyHausheer 13 years, 6 months ago


.  Useful Materials

  • Time in the Nucleus: Developmental Control of Replication Timing and Chromosome Architecture This article studies the correlation between replication timing and DNA and chromatin interaction maps. Although we did not learn anything about timing in the cell this chapter we have studied DNA replication and the structure of chromosomes. This article is a review of all the evidence linking the process of replication with the architecture of chromatin in the nucleus.  All eukaryotic cells replicate segments of their genomes in a timed sequence. This sequence changes during development. The sequence of how the sections of the DNA are replicated and the way that they change through development is conserved across some species. Which is a sign that there is a significance in this timing. This article studies what the importance or meaning of the links in between timing of DNA replication and chromatin structure may mean.
  • Nucleic Acids: DNA and RNA Visionlearning- This site has a brief and comprehensible article about nucleic acids and how they make up DNA and RNA. I thought it would have some really cool animations or videos or something because it was called visionlearning, which, unfortunately, it does not. However it does have some simple pictures which help you understand better. There is also a quiz for after you are done reading. It is ten simple questions and I got them all right on my first try! It also includes links to news articles, research, people, further exploration and more. Although this article is a bit elementary the website and information is very comprehensive. On the side bar it even has quotes! "I was shown Rosalind Franklin's X-ray photograph and "Whooo! That was a helix!", and a month later, we had the structure... " -James Watson, 1928
  • DNA Polymerase This site contains another article but this one focuses only on DNA polymerase. It claims that it is "the secret to life." It explains its major role in DNA replication. It focuses on how critical it is to life, how amazingly accurate it is, and how it is used in forensics. I found it really fascinating how Polymerase is used in forensics. It explained that in a drop of blood a full strand of DNA is rarely found. However, the small section of DNA can be put in a test tube and when DNA polymerase is added, it is multiplied. The DNA polymerase added is from a bacteria that lives in hot springs so that when the test tube is heated to initiate DNA replication, the polymerase is not destroyed. This is an example of how in lesson 4 of chapter 11 there ar different kinds of polymerase for different species is discussed. There is also a space-filling model of the DNA polymerase used in forensics.
  •  Nucleic Acid Database this is a database of three dimensional structure information of nucleic acids. It is extremely extensive. It contains many links for information about nucleic acids and what they do. We learned about the structure of nucleic acids in Lesson 2.


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